Characterization of human cytochrome P450 induction by pesticides

Khaled Abass, Virpi Lämsä, Petri Reponen, +5

Toxicology

Molecular PharmacologyBiochemistryPesticide-residue AnalysisMedicineToxicology +3

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

Liang Ma, Jeremy Barker, Changchun Zhou, +6

Biomaterials

Tissue EngineeringEngineeringBiomedical TechnologyMedical ImagingBiomedical Imaging +8

New <i>in Vitro</i> Tools to Study Human Constitutive Androstane Receptor (CAR) Biology: Discovery and Comparison of Human CAR Inverse Agonists

Jenni Küblbeck, Johanna Jyrkkärinne, Ferdinand Molnár, +8

Molecular Pharmaceutics

Molecular PharmacologyMedicinal ChemistrySilico AssaysBiochemistryFunctional Selectivity +12

Use of comprehensive screening methods to detect selective human CAR activators

Jenni Küblbeck, Tuomo Laitinen, Johanna Jyrkkärinne, +8

Biochemical Pharmacology

MedicineBioanalysisPharmacologyDrug DiscoveryHigh-throughput Screening

Insights into Ligand-Elicited Activation of Human Constitutive Androstane Receptor Based on Novel Agonists and Three-Dimensional Quantitative Structure−Activity Relationship

Johanna Jyrkkärinne, Björn Windshügel, Toni Rönkkö, +6

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyMedicinal ChemistryCar Agonist ActionDrug Design +15

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Jenni Küblbeck, Johanna Jyrkkärinne, Antti Poso, +4

Biochemical Pharmacology

Medicinal ChemistryBiochemistrySubstituted SulfonamidesMedicineNatural Sciences +8

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Jenni Küblbeck, Jenni J. Hakkarainen, Aleksanteri Petsalo, +5

Journal of Pharmaceutical Sciences

Caco-2 CellsEnergy MetabolismBiochemistryMitochondrial FunctionNatural Sciences +9

Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities

Minna Rahnasto‐Rilla, Joni Järvenpää, Marjo Huovinen, +6

Biomedicine & Pharmacotherapy

Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer

Carine M. Abdelmalek, Zexi Hu, Thales Kronenberger, +10

Journal of Medicinal Chemistry

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Sanna Toivonen, Melina M. Malinen, Jenni Küblbeck, +4

Tissue Engineering Part A

Tissue EngineeringEngineeringBiomaterials DesignHydrogel ModelsPetri Dish +22