Kazuki Hashiba

Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo

Yusuke Sato, Kazuki Hashiba, Kosuke Sasaki et al. · Journal of Controlled Release · 2019 · 170 citations

Different kinetics for the hepatic uptake of lipid nanoparticles between the apolipoprotein E/low density lipoprotein receptor and the N-acetyl-d-galactosamine/asialoglycoprotein receptor pathway

Yusuke Sato, Yoshiyuki Kinami, Kazuki Hashiba et al. · Journal of Controlled Release · 2020 · 85 citations

Nanoparticles, Lipid Preparation, Biochemistry +7

Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA

Kazuki Hashiba, Yusuke Sato, Masamitsu Taguchi et al. · Small Science · 2022 · 70 citations · Full text

Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles

Yusuke Sato, Nana Okabe, Yusuke Note et al. · Acta Biomaterialia · 2019 · 53 citations · Full text

Lipid Preparation, Nanomedicine, Scaffold Length +13

Overcoming thermostability challenges in mRNA–lipid nanoparticle systems with piperidine-based ionizable lipids

Kazuki Hashiba, Masamitsu Taguchi, Sachiko Sakamoto et al. · Communications Biology · 2024 · 52 citations · Full text