Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Daniel Taliun, Daniel Harris, Michael D. Kessler, +416

Nature

Normal Thoracic Aorta Diameter on Cardiac Computed Tomography in Healthy Asymptomatic Adults

Song Mao, Nasir Ahmadi, Birju A. Shah, +6

Academic Radiology

Cardiac Computed TomographyThoracic UltrasoundCardiologyHealthy Asymptomatic AdultsRadiology +1

Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods

Daniel H. Katz, Jeremy Robbins, Shuliang Deng, +16

Science Advances

Hypovitaminosis D in Chronic Kidney Disease

Rajnish Mehrotra, Dulcie Kermah, Matthew J. Budoff, +5

Clinical Journal of the American Society of Nephrology

Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes

John O’Sullivan, Jordan Morningstar, Qiong Yang, +18

Journal of Clinical Investigation

Unidentified PeaksMetabolic DisorderCardiometabolic RiskPathologyFatty Liver Disease +21

Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations

Michael Elgart, Genevieve Lyons, Santiago Romero‐Brufau, +20

Communications Biology

GeneticsPolygenic RiskGenetic EpidemiologyHuman PolymorphismDiverse Human Populations +18

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Joshua S. Weinstock, Jayakrishnan Gopakumar, Bala Bharathi Burugula, +506

Nature

Stem Cell ExpansionDevelopmental BiologyMedicineStem Cell MobilizationHematology +8

A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

Nuzulul Kurniansyah, Matthew Goodman, Tanika N. Kelly, +56

Nature Communications

Durable complete response to neoantigen-loaded dendritic-cell vaccine following anti-PD-1 therapy in metastatic gastric cancer

Zengqing Guo, Yuan Yuan, Chao Chen, +12

npj Precision Oncology

Trabecular Bone Mineral Density Measurement Using Thoracic and Lumbar Quantitative Computed Tomography

Matthew J. Budoff, Walid Khairallah, Dong Li, +6

Academic Radiology

Bone ImagingBone HealthMedical ImagingBiomechanicsOsteoarthritis +7