Phase I Trial of Intratumoral Injection of an Adenovirus Encoding Interleukin-12 for Advanced Digestive Tumors

Bruno Sangro, Guillermo Mazzolini, Juan Ruiz, +13

Journal of Clinical Oncology

Intratumoral Injection of Dendritic Cells Engineered to Secrete Interleukin-12 by Recombinant Adenovirus in Patients With Metastatic Gastrointestinal Carcinomas

Guillermo Mazzolini, Carlos Alfaro, Bruno Sangro, +16

Journal of Clinical Oncology

A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma

Bruno Sangro, Guillermo Mazzolini, Juan Ruiz, +10

Cancer Gene Therapy

HepatologyMedicinePathologyLiver CancerCancer Treatment +5

CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I

Nerea Zabaleta, Miren Barberia, Cristina Martín-Higueras, +14

Nature Communications

Safety and Liver Transduction Efficacy of rAAV5- <i>cohPBGD</i> in Nonhuman Primates: A Potential Therapy for Acute Intermittent Porphyria

Astrid Pañeda, Esperanza López‐Franco, Christine Kaeppel, +20

Human Gene Therapy

A new HDV mouse model identifies mitochondrial antiviral signaling protein (MAVS) as a key player in IFN-β induction

Lester Suárez-Amarán, Carla Usai, Marianna Di Scala, +14

Journal of Hepatology

Key PlayerMolecular VirologyViral ImmunityViral PathogenesisImmunology +7

Treatment with the senolytics dasatinib/quercetin reduces <scp>SARS‐CoV</scp>‐2‐related mortality in mice

Andrés Pastor Fernández, Antonio Rodríguez Bertos, Arantzazu Sierra‐Ramírez, +13

Aging Cell

TMEM173 Alternative Spliced Isoforms Modulate Viral Replication through the STING Pathway

Estefanía Rodríguez‐García, Cristina Olagüe, Sergio Rius‐Rocabert, +7

ImmunoHorizons

TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection

Carla Usai, Sheila Maestro, Gracián Camps, +7

JHEP Reports

IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression

Irene Gil-Fariña, Marianna Di Scala, Lucía Vanrell, +6

PLoS ONE

Adaptive Immune SystemImmunologyImmune RegulationImmunologic MechanismCd4 T Cell Responses +24