Genetic CD21 deficiency is associated with hypogammaglobulinemia

Jens Thiel, Lucas Kimmig, Ulrich Salzer, +19

Journal of Allergy and Clinical Immunology

Genetic DisorderGeneticsHematologyImmunologyHla Typing +4

USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis

Annette Aichem, Christiane Pelzer, Sebastian Łukasiak, +5

Nature Communications

Protein ChemistryProtein FunctionBiochemistryProtein AssemblyBispecific Conjugating Enzyme +4

The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation

Annette Aichem, Birte Kalveram, Valentina Spinnenhirn, +4

Journal of Cell Science

ImmunologyMolecular BiologyCell DeathInnate ImmunityCancer Biology +24

FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis

Neha Rani, Annette Aichem, Gunter Schmidtke, +2

Nature Communications

Proteomic TechnologyProtein FunctionBiochemistryProtein AssemblyProtein Folding +11

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells

Almut Dufner, Agnes Kisser, Sandra Niendorf, +12

Nature Immunology

Ubiquitin-specific Protease Usp8Protein FunctionCell RegulationLymphocyte DevelopmentMedicine +9

The ubiquitin-like modifier FAT10 decorates autophagy targeted S<i>almonella</i> and contributes to resistance of mice

Valentina Spinnenhirn, Hesso Farhan, Michael Basler, +3

Journal of Cell Science

The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation

Annette Aichem, Samira Anders, Nicola Catone, +11

Nature Communications

Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy

Nicola D. Roverato, Carolin Sailer, Nicola Catone, +3

Cell Reports

MitophagyUbiquitin-like Modifier Fat10Cell DeathCell AutophagySignaling Pathway +19

The ubiquitin-like modifier FAT10 interferes with SUMO activation

Annette Aichem, Carolin Sailer, Stella Ryu, +6

Nature Communications

Ca2+/Calmodulin-independent Activation of Calcineurin from Dictyostelium by Unsaturated Long Chain Fatty Acids

Ursula Kessen, Ralph SCHALOSKE, Annette Aichem, +1

Journal of Biological Chemistry