Otoferlin, Defective in a Human Deafness Form, Is Essential for Exocytosis at the Auditory Ribbon Synapse

Isabelle Roux, Saaïd Safieddine, Régis Nouvian, +11

Cell

NeuroanatomyMedicineAudiologyAuditory Ribbon SynapseArts +8

The structure of the myosin VI motor reveals the mechanism of directionality reversal

Julie Ménétrey, Amel Bahloul, Amber L. Wells, +4

Nature

MechanobiologyEngineeringMotor SystemMyosin Vi MotorMolecular Biology +8

Molecular Characterization of the Ankle-Link Complex in Cochlear Hair Cells and Its Role in the Hair Bundle Functioning

Nicolas Michalski, Vincent Michel, Amel Bahloul, +9

Journal of Neuroscience

Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice

Iman Sahly, Éric Dufour, Cataldo Schietroma, +15

The Journal of Cell Biology

Protein SecretionMolecular BiologyCytoskeletonCellular PhysiologyUsher 1 +19

Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia

Elisa Caberlotto, Vincent Michel, Isabelle Foucher, +13

Proceedings of the National Academy of Sciences

Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

Nicolas Michalski, Juan D. Goutman, Sarah M. Auclair, +17

eLife

Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses

Isabelle Roux, Suzanne Hosie, Stuart L. Johnson, +6

Human Molecular Genetics

Myosin ViCytoskeletonMechanotransductionNeurotransmissionCellular Neurobiology +23

Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

Amel Bahloul, Vincent Michel, Jean‐Pierre Hardelin, +5

Human Molecular Genetics

GeneticsMolecular BiologyCytoskeletonMechanotransductionHair Bundle +17

CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival

Vincent Michel, Kevin T. Booth, Pranav Patni, +19

EMBO Molecular Medicine

The unique insert in myosin VI is a structural calcium–calmodulin binding site

Amel Bahloul, Guillaume Chevreux, Amber L. Wells, +9

Proceedings of the National Academy of Sciences