Force-dependent conformational switch of α-catenin controls vinculin binding

Mingxi Yao, Wu Qiu, Ruchuan Liu, +8

Nature Communications

α-Catenin ControlsNatural SciencesReceptor (Biochemistry)Molecular BiologyConformational Study +5

The mechanical response of talin

Mingxi Yao, Benjamin T. Goult, Benjamin Klapholz, +6

Nature Communications

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

Mingxi Yao, Benjamin T. Goult, Hu Chen, +3

Scientific Reports

Dynamics of Equilibrium Folding and Unfolding Transitions of Titin Immunoglobulin Domain under Constant Forces

Hu Chen, Guohua Yuan, Ricksen S. Winardhi, +4

Journal of the American Chemical Society

Biophysical ModelingMolecular BiologyAnalytical UltracentrifugationProtein RefoldingFree Energy Cost +18

Mapping the Potential Energy Landscape of Intrinsically Disordered Proteins at Amino Acid Resolution

Valéry Ozenne, Robert C. Schneider, Mingxi Yao, +5

Journal of the American Chemical Society

Protein AssemblyIntrinsically Disordered ProteinsBiomolecular Structure PredictionStructural BioinformaticsMolecular Biology +17

Force- and cell state–dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry

Mingxi Yao, Ajay Tijore, Delfine Cheng, +6

Science Advances

Calcium EntryEngineeringCell State–dependent RecruitmentCell AdhesionCytoskeleton +22

Force-dependent binding of vinculin to α-catenin regulates cell–cell contact stability and collective cell behavior

Rima Seddiki, Gautham Hari Narayana Sankara Narayana, Pierre‐Olivier Strale, +8

Molecular Biology of the Cell

Cell AdhesionMolecular BiologyCytoskeletonCellular PhysiologyForce-dependent Binding +23

Mechanotransmission and Mechanosensing of Human alpha-Actinin 1

Shimin Le, Xian Hu, Mingxi Yao, +7

Cell Reports

Cell AdhesionFocal Adhesion MaturationMolecular BiologyCytoskeletonMechanotransduction +20

Elasticity of the Transition State Leading to an Unexpected Mechanical Stabilization of Titin Immunoglobulin Domains

Guohua Yuan, Shimin Le, Mingxi Yao, +4

Angewandte Chemie International Edition

MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels

Xiaonuo Ma, Yiechang Lin, Delfine Cheng, +12

Science

Molecular RegulationMolecular BiologyCytoskeletonCellular PhysiologyIntercellular Communication +17