Implication of inflammatory signaling pathways in obesity-induced insulin resistance

Jean‐François Tanti, Franck Ceppo, Jennifer Jager, +1

Frontiers in Endocrinology

Stress KinasesImmunologyImmune RegulationRenal InflammationObesity-induced Insulin Resistance +27

DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes

Bastien Vergoni, Pierre-Jean Cornejo, Jérôme Gilleron, +13

Diabetes

Dna DamageCell DeathMetabolic RemodelingInsulin SignalingOxidative Stress +14

Apical splenic nerve electrical stimulation discloses an anti-inflammatory pathway relying on adrenergic and nicotinic receptors in myeloid cells

Mélanie Guyot, Thomas Simon, Clara Panzolini, +9

Brain Behavior and Immunity

Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes

Mélanie Guyot, Thomas Simon, Franck Ceppo, +14

Nature Biotechnology

Autoimmune DiseasePhysiologyImmunologyDiabetesAutoimmunity +4

Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism

Simon Nicolas, Vincent Blasco‐Baqué, Audren Fournel, +14

Molecular Systems Biology

Maintenance of Macrophage Redox Status by ChREBP Limits Inflammation and Apoptosis and Protects against Advanced Atherosclerotic Lesion Formation

Vincent Sarrazy, Sophie Sore, Manon Viaud, +7

Cell Reports

Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

Jérôme Gilleron, Gwennaëlle Bouget, Stoyan Ivanov, +11

Cell Reports

Rab4b controls an early endosome sorting event by interacting with the γ subunit of the clathrin adaptor complex 1

Laura Perrin, Sandra Lacas‐Gervais, Jérôme Gilleron, +5

Journal of Cell Science

Molecular BiologyGlucose HomeostasisEarly EndosomeCellular PhysiologyEndocytic Pathway +15

Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4

Elodie M. Varin, Anne Wojtusciszyn, Christophe Broca, +6

Cell Death and Disease

Implication of the Tpl2 Kinase in Inflammatory Changes and Insulin Resistance Induced by the Interaction Between Adipocytes and Macrophages

Franck Ceppo, Flavien Berthou, Jennifer Jager, +3

Endocrinology

ImmunologyImmune RegulationInsulin SignalingInflammationMetabolic Syndrome +22