Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

Stéphane Vispé, Christophe Cazaux, Claire Lesca, +1

Nucleic Acids Research

Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA

Stéphane Vispé, Luc DeVries, Laurent Créancier, +10

Molecular Cancer Therapeutics

GeneticsMolecular BiologyTotal RnaTumor BiologyTranscriptional Regulation +20

F14512, a Potent Antitumor Agent Targeting Topoisomerase II Vectored into Cancer Cells via the Polyamine Transport System

Jean‐Marc Barret, Anna Kruczynski, Stéphane Vispé, +8

Cancer Research

Tumor BiologyDrug TargetingPolyamine Transport SystemPolymer-drug ConjugateMedicine +11

A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage

Stéphane Vispé, Tetsu M.C. Yung, Janelle Ritchot, +2

Proceedings of the National Academy of Sciences

Design, Synthesis and Biological Evaluation of 4‐Amino‐<i>N</i>‐(4‐aminophenyl)benzamide Analogues of Quinoline‐Based SGI‐1027 as Inhibitors of DNA Methylation

Elodie Rilova, Alexandre Erdmann, Christina Gros, +14

ChemMedChem

Crystal StructureDna MethylationChemical BiologyBenzamide AnaloguesPharmaceutical Chemistry +18

Physalin B, a novel inhibitor of the ubiquitin-proteasome pathway, triggers NOXA-associated apoptosis

Isabelle Vandenberghe, Laurent Créancier, Stéphane Vispé, +9

Biochemical Pharmacology

Triggers Noxa-associated ApoptosisPhysalin BProtein FunctionUbiquitin-proteasome PathwayMedicine +7

Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome

Stéphane Vispé, Isabelle Vandenberghe, Maxime Robin, +7

Biochemical Pharmacology

Medicinal ChemistryBioorganic ChemistryBiochemistryTopoisomerase IiNatural Sciences +7

Synthesis of conjugated spermine derivatives with 7-nitrobenzoxadiazole (NBD), rhodamine and bodipy as new fluorescent probes for the polyamine transport system

Yves Guminski, Martial Grousseaud, Sandrine Cugnasse, +7

Bioorganic & Medicinal Chemistry Letters

Polyamine Transport SystemEngineeringBioimagingNew Fluorescent ProbesChemical Probe +3

Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II

Viviane Brel, Jean‐Philippe Annereau, Stéphane Vispé, +3

Biochemical Pharmacology

Tumor BiologyDrug TargetingOncologyTopoisomerase IiMedicine +7

Poly(ADP-ribose) Polymerase-1 Is a Negative Regulator of HIV-1 Transcription through Competitive Binding to TAR RNA with Tat·Positive Transcription Elongation Factor b (p-TEFb) Complex

Marianne Parent, Tetsu M.C. Yung, Ann Rancourt, +7

Journal of Biological Chemistry