Design and Synthesis of Tetrahydropyridothieno[2,3-<i>d</i>]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency

Chia-Hsien Wu, Mohane Selvaraj Coumar, Chang-Ying Chu, +20

Journal of Medicinal Chemistry

Kinase InhibitorsMolecular BiologySide Chain ChiralityMaximal PotencyPharmaceutical Chemistry +18

A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment

Jen‐Shin Song, Chih-Chun Chang, Chien-Huang Wu, +14

Proceedings of the National Academy of Sciences

Interim safety analysis from TYTAN: A phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer.

Taroh Satoh, Yung‐Jue Bang, J. Wang, +7

Journal of Clinical Oncology

Gastrointestinal OncologyMedicineCancer ManagementPharmacologyCancer Cell Biology +10

A Novel CXCR4 Antagonist CX549 Induces Neuroprotection in Stroke Brain

Kuo‐Jen Wu, Seong‐Jin Yu, Kak‐Shan Shia, +7

Cell Transplantation

ImmunologyStroke BrainImmunotherapyCxcr4 Antagonist Amd3100Neuroinflammation +20

Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer

Shu‐Yu Lin, Yung Chang Hsu, Yi-Hui Peng, +17

Journal of Medicinal Chemistry

Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors

Ting‐Yueh Tsai, Tsu Hsu, Chiung‐Tong Chen, +13

Bioorganic & Medicinal Chemistry Letters

BiochemistryRational DesignMedicinePeptoidRational Drug Design +5

Stem Cell Mobilizers Targeting Chemokine Receptor CXCR4: Renoprotective Application in Acute Kidney Injury

Chien-Huang Wu, Jen‐Shin Song, Kuei-Hua Chang, +15

Journal of Medicinal Chemistry

Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor

Chien‐Huang Wu, Chun‐Ping Chang, Jen‐Shin Song, +13

ChemMedChem

Cell TherapyAdult Stem CellBiomedical EngineeringCxcr4 ReceptorRegenerative Medicine +15

(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV

Teng‐Kuang Yeh, Ting‐Yueh Tsai, Tsu Hsu, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryPharmaceutical ScienceBiochemistryMedicine +9

Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond

Chien-Huang Wu, Jen‐Shin Song, Hsuan-Hao Kuan, +15

Journal of Medicinal Chemistry