Aoife Murray

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Ivan Alić, Pollyanna Goh, Aoife Murray et al. · Molecular Psychiatry · 2020 · 118 citations · Full text

Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration

Aoife Murray, Audrey Letourneau, Claudia Canzonetta et al. · Stem Cells · 2015 · 77 citations · Full text

Adult Stem Cell, Cell Specialization, Epigenetics +20

Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations

Sergey I. Nikolaev, Marco Garieri, Federico Santoni et al. · Nature Communications · 2014 · 62 citations · Full text

Down Syndrome, Hematological Malignancy, Autoimmune Disease +8

Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering

Kunyu Zhang, Wai Hon Chooi, Shuang Liu et al. · Biomaterials · 2020 · 48 citations · Full text

Tissue Engineering, Cell-based Drug Delivery, Engineering +8

“Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain”

Ivan Alić, Pollyanna Goh, Aoife Murray et al. · 2020 · 26 citations · Full text

Cerebral Organoid, Neurochemical Biomarkers, Gene-dose-sensitive Ad-suppressor +20