Lawrence J. Shampine

Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia

Richard S.E. Keefe, Robert W. Buchanan, Robert M. Hamer et al. · Neuropsychopharmacology · 2009 · 190 citations · Full text

Proof-of-concept Trial, Psychoactive Drug, Psychiatry +14

Neuroactive Steroids are Altered in Schizophrenia and Bipolar Disorder: Relevance to Pathophysiology and Therapeutics

Robert D. Stevens, Lawrence J. Shampine, Veska Uzunova et al. · Neuropsychopharmacology · 2005 · 162 citations · Full text

Psychoactive Drug, Psychiatry, Psychotic Disorder +13

The Neurosteroid Allopregnanolone Is Reduced in Prefrontal Cortex in Alzheimer’s Disease

Christine E. Marx, William T. Trost, Lawrence J. Shampine et al. · Biological Psychiatry · 2006 · 143 citations

Neurodegenerative Diseases, Alzheimer's Disease, Prefrontal Cortex +9

Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: Candidate mechanism for superior efficacy?

Christine E. Marx, Lawrence J. Shampine, Gary E. Duncan et al. · Pharmacology Biochemistry and Behavior · 2006 · 81 citations

Rat Hippocampus, Superior Efficacy, Neuropsychology +12

Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: Implications for therapeutic actions

Lawrence J. Shampine, Rahul T. Khisti, William T. Trost et al. · Pharmacology Biochemistry and Behavior · 2006 · 80 citations

Psychoactive Drug, Fluoxetine Administration, Therapeutic Actions +9