Ivan H. Chan

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

John B. Mumm, Jan Emmerich, Xueqing Zhang et al. · Cancer Cell · 2011 · 414 citations · Full text

Life Sciences, Immunology, Oncology +10

IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without <i>De Novo</i> Infiltration from Secondary Lymphoid Organs

Jan Emmerich, John B. Mumm, Ivan H. Chan et al. · Cancer Research · 2012 · 267 citations

Medicine, Immunology, Oncology +17

PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients

Aung Naing, Jeffrey R. Infante, Kyriakos P. Papadopoulos et al. · Cancer Cell · 2018 · 251 citations · Full text

Life Sciences, Immunology, Oncology +17

Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors

Aung Naing, Kyriakos P. Papadopoulos, Karen A. Autio et al. · Journal of Clinical Oncology · 2016 · 217 citations

Medicine, Immunology, Oncology +17

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells

Ivan H. Chan, Renu Jain, Marlowe S. Tessmer et al. · Mucosal Immunology · 2013 · 143 citations · Full text

Life Sciences, Immunology, Oncology +12