Naoki Orimoto

Investigation of the Bioactive Conformation of Histamine H₃ Receptor Antagonists by the Cyclopropylic Strain-Based Conformational Restriction Strategy

Mizuki Watanabe, Takatsugu Hirokawa, Takaaki Kobayashi et al. · Journal of Medicinal Chemistry · 2010 · 42 citations · Full text

Suplatast Tosilate Inhibits Histamine Signaling by Direct and Indirect Down-Regulation of Histamine H1 Receptor Gene Expression through Suppression of Histidine Decarboxylase and IL-4 Gene Transcriptions

Masum Shahriar, Hiroyuki Mizuguchi, Kazutaka Maeyama et al. · The Journal of Immunology · 2009 · 39 citations · Full text

Asthma, Inflammatory Lung Disease, Allergy Medicine +23

Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: Histamine H₃and/or H₄receptor ligands with the 2,3-methanobutane backbone

Mizuki Watanabe, Takaaki Kobayashi, Takatsugu Hirokawa et al. · Organic & Biomolecular Chemistry · 2011 · 15 citations

Suplatast tosilate alleviates nasal symptoms through the suppression of nuclear factor of activated T-cells-mediated IL-9 gene expression in toluene-2,4-diisocyanate-sensitized rats

Hiroyuki Mizuguchi, Naoki Orimoto, Takuya Kadota et al. · Journal of Pharmacological Sciences · 2016 · 14 citations · Full text

Asthma, Inflammatory Lung Disease, Allergy Medicine +21

Protein Kinase C Activation by Helicobacter pylori in Human Gastric Epithelial Cells Limits Interleukin-8 Production Through Suppression of Extracellular Signal-Regulated Kinase

Yoshihisa Nozawa, Katsushi Nishihara, Yushiro Akizawa et al. · Journal of Pharmacological Sciences · 2004 · 13 citations · Full text