Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

Yvonne Y. Yip, Frantz Victor, Jason Lamar, +16

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +7

P4 and P1′ optimization of bicycloproline P2 bearing tetrapeptidyl α-ketoamides as HCV protease inhibitors

Yvonne Y. Yip, Frantz Victor, Jason Lamar, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesBicycloproline P2 Bearing +7

Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR

Jason Lamar, Jingdan Hu, Ana B. Bueno, +9

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineNatural SciencesPeptide LibraryMechanism Of Action +6

P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl α-ketoamide based HCV protease inhibitors

Frantz Victor, Jason Lamar, Nancy Snyder, +7

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineNatural SciencesP3 OptimizationAntiviral Drug Development +9

Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase

Michaël Génin, Isabel C. Gonzalez Valcarcel, William G. Holloway, +11

Journal of Medicinal Chemistry

Bioorganic ChemistryPharmacotherapyChemical BiologyInsulin SignalingPharmaceutical Chemistry +21

Design and Synthesis of Dual Peroxisome Proliferator-Activated Receptors γ and δ Agonists as Novel Euglycemic Agents with a Reduced Weight Gain Profile

Yanping Xu, Garret J. Etgen, Carol L. Broderick, +13

Journal of Medicinal Chemistry

P3 cap modified Phe*-Ala series BACE inhibitors

Shuhui Chen, Jason Lamar, Deqi Guo, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentPharmacotherapyP3 Cap +4

Design and synthesis of a novel class of dual PPARγ/δ agonists

Isabel Chirivella González, Jason Lamar, Fátima Iradier, +10

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineNatural SciencesDual Pparγ/δ Agonists +7

Synthesis and evaluation of tripeptidyl α-Ketoamides as human rhinovirus 3C protease inhibitors

Shu‐Hui Chen, Jason Lamar, Frantz Victor, +5

Bioorganic & Medicinal Chemistry Letters

Protease InhibitorsMedicineAntiviral Drug DevelopmentAntiviral TherapyVirology +6

P1 and P1; Optimization of [3,4]-Bicycloproline P2 Incorporated Tetrapeptidyl α-Ketoamide Based HCV Protease Inhibitors

Shuhui Chen, Jason Lamar, Yvonne Y. Yip, +9

Letters in Drug Design & Discovery