Samuel J. Seguin

HspB8 Chaperone Activity toward Poly(Q)-containing Proteins Depends on Its Association with Bag3, a Stimulator of Macroautophagy

Serena Carra, Samuel J. Seguin, Herman Lambert et al. · Journal of Biological Chemistry · 2007 · 349 citations · Full text

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

Massimo Ganassi, Daniel Matějů, Ilaria Bigi et al. · Molecular Cell · 2016 · 304 citations · Full text

Surveillance Function, Biochemistry, Protein Folding +6

Identification of the key structural motifs involved in HspB8/HspB6–Bag3 interaction

Margit Fuchs, Dominic Poirier, Samuel J. Seguin et al. · Biochemical Journal · 2009 · 184 citations · Full text

Structural Bioinformatics, Protein Assembly, Biomolecular Structure Prediction +17

Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly

Samuel J. Seguin, Federica Morelli, Jonathan Vinet et al. · Cell Death and Differentiation · 2014 · 178 citations · Full text

Mitophagy, Molecular Biology, Cytoskeleton +20

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity

V. Crippa, M.E. Cicardi, Nandini Ramesh et al. · Human Molecular Genetics · 2016 · 90 citations · Full text

Tdp-43-mediated Toxicity, Apoptosis, Molecular Biology +20