Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa

Mrinal K. Sarkar, Grace A. Hile, Lam C. Tsoi, +18

Annals of the Rheumatic Diseases

Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis

Feiyang Ma, Olesya Plazyo, Allison C. Billi, +25

Nature Communications

Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation

Allison C. Billi, Feiyang Ma, Olesya Plazyo, +14

Science Translational Medicine

Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus

Lam C. Tsoi, Grace A. Hile, Céline C. Berthier, +11

The Journal of Immunology

Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis

Feiyang Ma, Pei‐Suen Tsou, Mehrnaz Gharaee‐Kermani, +22

Nature Communications

Staphylococcus aureus Colonization Is Increased on Lupus Skin Lesions and Is Promoted by IFN-Mediated Barrier Disruption

Sirisha Sirobhushanam, Navya Parsa, Tamra J. Reed, +9

Journal of Investigative Dermatology

Ifn-mediated Barrier DisruptionLupusCutaneous BiologyPathogenesisImmunology +7

IL18-containing 5-gene signature distinguishes histologically identical dermatomyositis and lupus erythematosus skin lesions

Lam C. Tsoi, Mehrnaz Gharaee‐Kermani, Céline C. Berthier, +10

JCI Insight

ImmunodeficienciesImmunologyImmune RegulationInnate ImmunityDermatology +23

Quantification of 19 Aldehydes in Human Serum by Headspace SPME/GC/High-Resolution Mass Spectrometry

Lalith K. Silva, Grace A. Hile, Kimberly M. Capella, +4

Environmental Science & Technology

Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab

Feiyang Ma, Mehrnaz Gharaee‐Kermani, Lam C. Tsoi, +17

Journal of Allergy and Clinical Immunology

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity

Benjamin Klein, Mack B. Reynolds, Bin Xu, +16

Science Immunology