Kai Huang

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

Xin Chen, Wanting He, Lichen Hu et al. · Cell Research · 2016 · 823 citations · Full text

Mlkl Channel-mediated Necroptosis, Apoptosis, Cell Death +18

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

Katelyn O’Neill, Kai Huang, Jingjing Zhang et al. · Genes & Development · 2016 · 311 citations · Full text

Mitophagy, Organelle Dynamic, Apoptosis +18

Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

Yugang Jiang, Mian Wang, Kai Huang et al. · Biochemical and Biophysical Research Communications · 2012 · 152 citations

Inflammation, Low-density Lipoprotein, Immunology +8

BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis

Kai Huang, Katelyn O’Neill, Jian Li et al. · Cell Research · 2019 · 132 citations · Full text

Medicine, Apoptosis, Cell Death +4

Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis

Kai Huang, Jingjing Zhang, Katelyn O’Neill et al. · Journal of Biological Chemistry · 2016 · 129 citations · Full text

Signal Transduction, Trail-induced Apoptosis, Mitochondrial Function +10