Structured crowdsourcing enables convolutional segmentation of histology images

Mohamed Amgad, Habiba Elfandy, Hagar Hussein, +28

Bioinformatics

The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism

Yahya Salma, Élodie Lafont, Stéphane Carpentier, +4

Biochemical Pharmacology

BiochemistryMedicinePhotocarcinogenesisApoptosisMelanoma +7

First Characterization of The Venom from Apis mellifera syriaca, A Honeybee from The Middle East Region

Jacinthe Frangieh, Yahya Salma, Katia Haddad, +4

Toxins

Flexible and enantioselective access to jaspine B and biologically active chain-modified analogues thereof

Yahya Salma, Stéphanie Ballereau, Carine Maaliki, +3

Organic & Biomolecular Chemistry

Chain-modified AnaloguesBioorganic ChemistryAntiparasitic AgentJaspine BChemical Biology +14

Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia

Rim Trad, Walid Warda, Vincent Alcazer, +20

Journal for ImmunoTherapy of Cancer

Overcoming target epitope masking resistance that can occur on low-antigen-expresser AML blasts after IL-1RAP chimeric antigen receptor T cell therapy using the inducible caspase 9 suicide gene safety switch

Walid Warda, Mathieu Neto Da Rocha, Rim Trad, +7

Cancer Gene Therapy

The Cytotoxic and Apoptotic Effects of the Brown Algae Colpomenia sinuosa are Mediated by the Generation of Reactive Oxygen Species

Reem Al Monla, Zeina Dassouki, Achraf Kouzayha, +3

Molecules

Enantioselective access to a versatile 4-oxazolidinonecarbaldehyde and application to the synthesis of a cytotoxic jaspine B truncated analogue

Yves Génisson, Lydia Lamandé, Yahya Salma, +3

Tetrahedron Asymmetry

Bioorganic ChemistryBiochemistryMedicineNatural SciencesEnantioselective Access +6

Single- and double-chained truncated jaspine B analogues: asymmetric synthesis, biological evaluation and theoretical study of an unexpected 5-endo-dig process

Yahya Salma, Stéphanie Ballereau, Sonia Mallet‐Ladeira, +4

Tetrahedron

Combinatorial ChemistryBioorganic ChemistryBiochemistryNatural SciencesAsymmetric Synthesis +8

Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol

V. Faugeroux, Yves Génisson, Yahya Salma, +2

Bioorganic & Medicinal Chemistry

Antitubercular Agent EthambutolBiochemistryMedicineRational Drug DesignBiological Evaluation +3