Efraim Shek

Delivery of a Quaternary Pyridinium Salt Across the Blood-Brain Barrier by Its Dihydropyridine Derivative

Nicholas Bodor, Efraim Shek, Tsunehiko Higuchi · Science · 1975 · 73 citations

Improved delivery through biological membranes. 1. Synthesis and properties of 1-methyl-1,6-dihydropyridine-2-carbaldoxime, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride

Nicolae Bodor, Efraim Shek, Takeru Higuchi · Journal of Medicinal Chemistry · 1976 · 63 citations

Bioorganic Chemistry, Organic Chemistry, Biological Membranes +17

Sustained brain-specific delivery of estradiol causes long-term suppression of luteinizing hormone secretion

James W. Simpkins, Jill McCornack, Kerry Estes et al. · Journal of Medicinal Chemistry · 1986 · 51 citations

Neuroendocrinology, Altmetric Attention Score, Pharmacotherapy +26

Improved delivery through biological membranes. 3. Delivery of N-methylpyridinium-2-carbaldoxime chloride through the blood-brain barrier in its dihydropyridine pro-drug form

Efraim Shek, Takeru Higuchi, Nicolae Bodor · Journal of Medicinal Chemistry · 1976 · 51 citations

Improved delivery through biological membranes. 38. Brain-specific chemical delivery systems for .beta.-lactam antibiotics. Synthesis and properties of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin

Emil Pop, Whei Mei Wu, Efraim Shek et al. · Journal of Medicinal Chemistry · 1989 · 45 citations