Jeffrey Chen

Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1)

Leif Dahlberg, R. Clark Billinghurst, Paul Manner et al. · Arthritis & Rheumatism · 2000 · 243 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Tea Pemovska, Eric F. Johnson, Mika Kontro et al. · Nature · 2015 · 240 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase

R. Clark Billinghurst, William Ka Kei Wu, Mirela Ionescu et al. · Arthritis & Rheumatism · 2000 · 161 citations

Dentistry, Immunology, Pathology +17

PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity

Jing Yuan, Pramod P. Mehta, Min-Jean Yin et al. · Molecular Cancer Therapeutics · 2011 · 161 citations · Full text

Medicine, Oncology, Pharmacology +16

Minimum 5-Year Outcomes of Robotic-assisted Primary Total Hip Arthroplasty With a Nested Comparison Against Manual Primary Total Hip Arthroplasty: A Propensity Score–Matched Study

Benjamin G. Domb, Jeffrey Chen, Ajay C. Lall et al. · Journal of the American Academy of Orthopaedic Surgeons · 2020 · 117 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +14