Ronald E. Tynes

Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells

Uta Eckhardt, Alice Schroeder, Bruno Stieger et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 1999 · 140 citations

The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6.

Volker Fischer, Birgit A. P. M. Vogels, Gerald Maurer et al. · Journal of Pharmacology and Experimental Therapeutics · 1992 · 126 citations

Identification of distinct hepatic and pulmonary forms of microsomal flavin-containing monooxygenase in the mouse and rabbit

Ronald E. Tynes, Patrick J. Sabourin, Ernest Hodgson · Biochemical and Biophysical Research Communications · 1985 · 104 citations

Biochemistry, Medicine, Liver Physiology +8

The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A. Implications for drug-drug interactions and pharmacological activity of the main metabolite.

Volker Fischer, Alicia Rodríguez‐Gascón, Francis Heitz et al. · PubMed · 1998 · 104 citations

Main Metabolite, Metabolomic Profiling, Pharmacotherapy +16

Substrate specificity of the rat liver Na⁺-bile salt cotransporter in<i>Xenopus laevis</i>oocytes and in CHO cells

Alice Schroeder, Uta Eckhardt, Bruno Stieger et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 1998 · 103 citations

Cholangiopathies, Cholangiocyte Biology, Cellular Physiology +25