Galloflavin (CAS 568‐80‐9): A Novel Inhibitor of Lactate Dehydrogenase

Marcella Manerba, Marina Vettraino, L. Fiume, +6

ChemMedChem

Molecular PharmacologyMetabolic PathwaysGlycolysis InhibitorsCellular EnzymologyBiochemistry +13

Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways

Fulvia Farabegoli, Marina Vettraino, Marcella Manerba, +3

European Journal of Pharmaceutical Sciences

Breast OncologyEndocrine-related CancerMedicineApoptosisCell Death +7

Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells

Marcella Manerba, Lorenza Di Ianni, Marzia Govoni, +3

European Journal of Pharmaceutical Sciences

InflammationAnti-inflammatoryLactate Dehydrogenase InhibitorsMedicineColon Cancer Cells +5

Impairment of Aerobic Glycolysis by Inhibitors of Lactic Dehydrogenase Hinders the Growth of Human Hepatocellular Carcinoma Cell Lines

L. Fiume, Marcella Manerba, Marina Vettraino, +1

Pharmacology

Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin-1

Marina Vettraino, Marcella Manerba, Marzia Govoni, +1

Anti-Cancer Drugs

ImmunologyPathologyBurkitt Lymphoma CellsMetabolic RemodelingImmunotherapy +19

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells

Marinella Roberti, Fabrizio Schipani, Greta Bagnolini, +14

European Journal of Medicinal Chemistry

Pancreatic CancerMedicineHomologous RecombinationCancer Cell BiologyPancreatic Cancer Cells +7

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib

Greta Bagnolini, Domenico Milano, Marcella Manerba, +16

Journal of Medicinal Chemistry

Lactate dehydrogenase inhibitors sensitize lymphoma cells to cisplatin without enhancing the drug effects on immortalized normal lymphocytes

Marcella Manerba, Lorenza Di Ianni, L. Fiume, +3

European Journal of Pharmaceutical Sciences

Lactate Dehydrogenase InhibitorsMedicineLymphoma CellsImmunologyImmune Checkpoint Inhibitor +7

Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors

L. Fiume, Marina Vettraino, Marcella Manerba, +1

Pharmacological Research

BiochemistryMedicineReceptor Tyrosine KinaseLactic DehydrogenaseMulti-targeted Kinase Inhibitors +5

Synthetic Lethality Triggered by Combining Olaparib with BRCA2–Rad51 Disruptors

Federico Falchi, Elisa Giacomini, Tiziana Masini, +12

ACS Chemical Biology