Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1

H. Y. Xu, Hongfang Zhao, Chunyong Ding, +11

Signal Transduction and Targeted Therapy

Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy

Bingshe Han, Dongkyoo Park, Rui Li, +13

Cancer Cell

MedicineBronchial NeoplasmLung Cancer TherapyAnti-cancer AgentPharmacology +2

Small-molecule Bax agonists for cancer therapy

Meiguo Xin, Rui Li, Maohua Xie, +12

Nature Communications

MedicineSmall-molecule Bax AgonistsTumor TargetingAnti-cancer AgentPharmacology +2

Discovery of <i>O</i>-Alkylamino-Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents

Haijun Chen, Zhengduo Yang, Chunyong Ding, +6

ACS Medicinal Chemistry Letters

Acid‐Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer

Fangmin Chen, Tianliang Li, Huijuan Zhang, +12

Advanced Materials

Novel Nitrogen-Enriched Oridonin Analogues with Thiazole-Fused A-Ring: Protecting Group-Free Synthesis, Enhanced Anticancer Profile, and Improved Aqueous Solubility

Chunyong Ding, Yusong Zhang, Haijun Chen, +6

Journal of Medicinal Chemistry

Thiazole-fused A-ringMedicinal ChemistryComplex Ent-kaurane DiterpenoidEnhanced Anticancer ProfileAqueous Solubility +12

Fragment-based drug design and identification of HJC0123 , a novel orally bioavailable STAT3 inhibitor for cancer therapy

Haijun Chen, Zhengduo Yang, Chunyong Ding, +6

European Journal of Medicinal Chemistry

Cancer TherapyBioavailable Stat3 InhibitorMedicineFragment-based Drug DesignPharmacotherapy +7

Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer

Fangyuan Zhou, Bing Feng, Tingting Wang, +8

Advanced Functional Materials

Ethylene GlycolBreast OncologyNanotherapeuticsUltrafast Drug ReleaseTumor Biology +20

Oridonin Ring A-Based Diverse Constructions of Enone Functionality: Identification of Novel Dienone Analogues Effective for Highly Aggressive Breast Cancer by Inducing Apoptosis

Chunyong Ding, Yusong Zhang, Haijun Chen, +8

Journal of Medicinal Chemistry

Natural ScaffoldBreast OncologyCell DeathPharmaceutical ChemistryMedicinal Chemistry +17

Acid-Promoted D-A-D Type Far-Red Fluorescent Probe with High Photostability for Lysosomal Nitric Oxide Imaging

Fengyang Wang, Shujuan Yu, Zhiai Xu, +9

Analytical Chemistry

EngineeringHigh PhotostabilityMolecular BiologyRedox BiologyPhosphorescence Imaging +20