Stress relaxing hyaluronic acid-collagen hydrogels promote cell spreading, fiber remodeling, and focal adhesion formation in 3D cell culture

Junzhe Lou, Ryan S. Stowers, Sungmin Nam, +2

Biomaterials

Tissue EngineeringEngineeringMedicineBiomaterials DesignBiofabrication +11

Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments

Katrina M. Wisdom, Kolade Adebowale, Julie Chang, +8

Nature Communications

Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels

Sungmin Nam, Kenneth H. Hu, Manish J. Butte, +1

Proceedings of the National Academy of Sciences

Varying PEG density to control stress relaxation in alginate-PEG hydrogels for 3D cell culture studies

Sungmin Nam, Ryan S. Stowers, Junzhe Lou, +2

Biomaterials

Tissue EngineeringHydrogelsBiopolymer GelEngineeringStress Relaxation +9

Enhanced substrate stress relaxation promotes filopodia-mediated cell migration

Kolade Adebowale, Ze Gong, Jay Hou, +8

Nature Materials

Filopodia-mediated Cell MigrationCell MigrationCell MotilityCell BiomechanicsCytoskeleton +4

Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility

Ryan S. Stowers, Anna Shcherbina, Johnny Israeli, +8

Nature Biomedical Engineering

ChromatinChromatin AccessibilityChromatin StructureChromatin RemodelingMedicine +12

Viscoplasticity Enables Mechanical Remodeling of Matrix by Cells

Sungmin Nam, Joanna Lee, Douglas Brownfield, +1

Biophysical Journal

MechanobiologyEngineeringMechanical EngineeringBiomechanicsCell Biomechanics +3

YAP-independent mechanotransduction drives breast cancer progression

Joanna Y. Lee, Jessica Chang, Antonia A. Dominguez, +7

Nature Communications

Breast OncologyEngineeringTissue StiffnessMechanotransductionCellular Physiology +14

Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27 ^Kip1 signaling axis

Sungmin Nam, Vivek Kumar Gupta, Hong-Pyo Lee, +7

Science Advances

Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces

Ehsan Ban, James Franklin, Sungmin Nam, +6

Biophysical Journal

MechanobiologyTissue EngineeringEngineeringCollagen Networks InducedBiomechanics +12