An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy

Sarah Chan, Nicole A. Belmar, Sun K. Ho, +38

Nature Cancer

A non-clinical comparative study of IL-23 antibodies in psoriasis

Li Zhou, Yibing Wang, Qi Wan, +17

mAbs

Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors

Darren C. Phillips, Fritz G. Buchanan, Dong Cheng, +16

Cancer Research

Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity

Sun K. Ho, Zhenghai Xu, Archana Thakur, +15

Molecular Cancer Therapeutics

Quantitative ligand and receptor binding studies reveal the mechanism of interleukin-36 (IL-36) pathway activation

Li Zhou, Viktor Todorović, Steve Kakavas, +9

Journal of Biological Chemistry

<scp>IL</scp>‐36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis

Zhi Su, Stephanie Paulsboe, J. Wetter, +19

Experimental Dermatology

Structure-Based Design of A-1293102, a Potent and Selective BCL-X_L Inhibitor

Zhi‐Fu Tao, Xilu Wang, Jun Chen, +13

ACS Medicinal Chemistry Letters

Disulfide-Mediated Stabilization of the IκB Kinase Binding Domain of NF-κB Essential Modulator (NEMO)

Li Zhou, Alan T. Yeo, Carmine Ballarano, +4

Biochemistry

PULSE SPR: A High Throughput Method to Evaluate the Domain Stability of Antibodies

Li Zhou, Jun Zhang, Enrico L. DiGiammarino, +7

Analytical Chemistry

Low Ph StabilityEngineeringPulse SprImmunologyImmunotherapy +21

[Pharmacological actions of dehydrocorydaline on cardiovascular system (author's transl)].

Xuanting Jiang, Qiaoqun Wu, Hai-Long Shi, +7

PubMed

Molecular PharmacologyCardiovascular SystemMedicinePhysiologyCardiovascular Pharmacology +4