The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain

Barbara Costa, Anna Elisa Trovato, Francesca Comelli, +2

European Journal of Pharmacology

Effective Therapeutic AgentCannabis UsePain TherapyHealth SciencesAddiction +10

Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation

Barbara Costa, Gabriella Giagnoni, Chiara Franke, +2

British Journal of Pharmacology

Pain MedicineImmunologyMolecular PainPharmacotherapyNonpsychoactive Cannabinoid +15

Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw

Barbara Costa, Mariapia Colleoni, Silvia Conti, +4

Naunyn-Schmiedeberg s Archives of Pharmacology

InflammationCannabis UseAnti-inflammatoryOral Anti-inflammatory ActivityPharmacology +5

The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1β, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice

Cataldo Martucci, Anna Elisa Trovato, Barbara Costa, +8

Pain

Pain DisordersPeripheral Nerve InjuryPain MedicineSynaptic TransmissionNeuropathic Pain +22

Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti‐inflammatory and antioxidant activity

A Valsecchi, Silvia Franchi, Alberto E. Panerai, +3

Journal of Neurochemistry

Pain DisordersPain MedicineAntioxidant ActivityNeuropathic PainMolecular Pain +20

Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve

Barbara Costa, Anna Elisa Trovato, Mariapia Colleoni, +3

Pain

AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain

Barbara Costa, Dario Siniscalco, Anna Elisa Trovato, +6

British Journal of Pharmacology

Pain TherapyPain MedicineNitric OxideImmunologyNeuropathic Pain +17

Transient early expression of TNF-α in sciatic nerve and dorsal root ganglia in a mouse model of painful peripheral neuropathy

Paola Sacerdote, Silvia Franchi, Anna Elisa Trovato, +3

Neuroscience Letters

Transient Early ExpressionMolecular NeurosciencePainful Peripheral NeuropathyPeripheral Nerve InjuryMedicine +10

Repeated treatment with the synthetic cannabinoid WIN 55,212‐2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain

Barbara Costa, Mariapia Colleoni, Silvia Conti, +4

British Journal of Pharmacology

The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse

Marinos Kallikourdis, Anna Elisa Trovato, Fabio Anselmi, +5

Blood