Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

Aaron Goldman, Biswanath Majumder, Andrew Dhawan, +5

Nature Communications

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype

Marcelo Boareto, Mohit Kumar Jolly, Aaron Goldman, +6

Journal of The Royal Society Interface

NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells

Wucheng Qi, Kishore Shakalya, A Stejskal, +4

Oncogene

MedicineInduces ApoptosisApoptosisCell DeathAntisense Therapy +6

Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition

Roman A. Eliseev, Gleb Filippov, Janice Velos, +4

Neurobiology of Aging

MitophagyPermeability TransitionBiochemistryMitochondrial FunctionNatural Sciences +11

Reporter nanoparticle that monitors its anticancer efficacy in real time

Ashish Kulkarni, Poornima Rao, Siva Kumar Natarajan, +7

Proceedings of the National Academy of Sciences

Rationally Designed 2-in-1 Nanoparticles Can Overcome Adaptive Resistance in Cancer

Aaron Goldman, Ashish Kulkarni, Mohammad Kohandel, +5

ACS Nano

NanoparticlesEngineeringBiomedical EngineeringAdaptive ResistanceTumor Biology +18

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance

Aaron Goldman, Sachin Khiste, Elizaveta Freinkman, +13

Science Signaling

A novel mechanism of acid and bile acid-induced DNA damage involving Na ⁺ /H ⁺ exchanger: implication for Barrett's oesophagus

Aaron Goldman, Mohammad Shahidullah, David Goldman, +4

Gut

Long-Range PCR and Next-Generation Sequencing of BRCA1 and BRCA2 in Breast Cancer

Hilmi Özçelik, Xuejiang Shi, Martin C. Chang, +10

Journal of Molecular Diagnostics

Breast OncologyEngineeringTumor HeterogeneityMedicineNext-generation Sequencing +9

Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow

Gizem Calibasi‐Kocal, Sinan Güven, Kira Foygel, +6

Scientific Reports