DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs<i>in Vitro</i>and<i>in Vivo</i>

Karen Thompson, Elham Khajehali, Sophie J. Bradley, +19

ACS Pharmacology & Translational Science

Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor

Elham Khajehali, Daniel T. Malone, Michelle Glass, +3

Molecular Pharmacology

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

Katie Leach, Karen J. Gregory, Irina Kufareva, +6

Cell Research

Molecular PharmacologyDrug TargetBiochemistryStructural UnderstandingMedicine +10

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Ziva Vuckovic, Jinan Wang, Vi Pham, +21

eLife

Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

Elham Khajehali, Céline Valant, Manuela Jörg, +6

Biochemical Pharmacology

Negative allosteric modulators of the human calcium‐sensing receptor bind to overlapping and distinct sites within the 7‐transmembrane domain

Tracy M. Josephs, Andrew N. Keller, Elham Khajehali, +7

British Journal of Pharmacology

M ₁ muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease

Louis Dwomoh, Mario Rossi, Miriam Scarpa, +11

Science Signaling

Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M₁ Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles

Juliana C.C. Dallagnol, Elham Khajehali, Emma T. van der Westhuizen, +6

Journal of Medicinal Chemistry

Inhibitory effects of fluoxetine on the secretion of inflammatory mediators and JAK/STAT3 and JNK/TLR4 gene expression

Hoda Mojiri-Forushani, Elham Khajehali, Maryam Adelipour, +1

Molecular Biology Reports

InflammationJnk/tlr4 Gene ExpressionCytokineInhibitory EffectsAnti-inflammatory +11

Dual Action Calcium-Sensing Receptor Modulator Unmasks Novel Mode-Switching Mechanism

Karen J. Gregory, Irina Kufareva, Andrew N. Keller, +8

ACS Pharmacology & Translational Science

Negative Allosteric ModulatorsDrug TargetingSignal TransductionFunctional SelectivityCell Signaling +12