Modelling changes in glutathione homeostasis as a function of quinone redox metabolism

Ross A. Kelly, Joseph Leedale, Dominic Calleja, +4

Scientific Reports

Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia

James Bagnall, Joseph Leedale, Sarah E. Taylor, +5

Journal of Biological Chemistry

Signal TransductionTight ControlRedox RegulatorPhysiologyHypoxia (Medicine) +8

Multiscale modelling of drug transport and metabolism in liver spheroids

Joseph Leedale, Jonathan A. Kyffin, Amy L. Harding, +6

Interface Focus

Characterisation of a functional rat hepatocyte spheroid model

Jonathan A. Kyffin, Parveen Sharma, Joseph Leedale, +5

Toxicology in Vitro

Projecting malaria hazard from climate change in eastern Africa using large ensembles to estimate uncertainty

Joseph Leedale, Adrian M. Tompkins, Cyril Caminade, +3

Geospatial health

ClimatologyMeteorologyFuture Climatic ChangeEngineeringEastern Africa +12

Environmental change and Rift Valley fever in eastern Africa: projecting beyond HEALTHY FUTURES

David Taylor, Michael Hagenlocher, Anne Jones, +3

Geospatial health

Eastern AfricaMalariaLiverpool RvfEpidemiological DynamicDisease Outbreak +15

Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems

Joseph Leedale, Anne Herrmann, James Bagnall, +4

Mathematical Biosciences

Cell Culture SystemsMedicineHypoxia (Medicine)Single CellsCell Culture +7

A dynamic, climate-driven model of Rift Valley fever

Joseph Leedale, Anne Jones, Cyril Caminade, +1

Geospatial health

ClimatologyMeteorologyInfectious Disease ModellingEngineeringRvf Outbreak Susceptibility +8

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture

Ross A. Kelly, Joseph Leedale, Andy Harrell, +4

PLoS ONE

Extracellular EnvironmentCell CultureMetabolic RemodelingCell GrowthMetabolic Model +20

Mathematical modelling of oxygen gradients in stem cell-derived liver tissue

Joseph Leedale, Baltasar Lucendo‐Villarin, Jose Meseguer-Ripolles, +3

PLoS ONE