CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

Hong Xu, Marco Di Antonio, Steven McKinney, +36

Nature Communications

Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome

Keith Wheaton, Denise Campuzano, Weili Ma, +4

Molecular and Cellular Biology

GeneticsMolecular BiologyCell CycleP53 ActivationTranscriptional Regulation +16

A cross-species proteomic map reveals neoteny of human synapse development

Li Wang, Kaifang Pang, Li Zhou, +22

Nature

Proteomic TechnologyDevelopmental BiologyMedicineGeneticsProteomics +3

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

Parasvi S. Patel, Karan Joshua Abraham, Kiran Kumar Naidu Guturi, +24

Journal of Clinical Investigation

Tumor BiologyTranscriptional RegulationGenome InstabilityMedicineR-loop Resolution +13

Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA–DNA hybrids

Karan Joshua Abraham, Janet N.Y. Chan, Jayesh S. Salvi, +9

Nucleic Acids Research

Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase

Shengjie Feng, Cristina Puchades, Juyeon Ko, +12

Nature Communications

Mapping <scp>DNA</scp> damage‐dependent genetic interactions in yeast via party mating and barcode fusion genetics

J. Javier Díaz-Mejía, Albi Celaj, Joseph Mellor, +18

Molecular Systems Biology

Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma

Lukas Tamayo-Orrego, David Gallo, Frédéric Racicot, +8

Nature Cancer

Tumor BiologyGenome InstabilitySomatic VariantTumor HeterogeneityGenetics +6

RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

Rehna Krishnan, Mariah Lapierre, Brandon Gautreau, +30

Nucleic Acids Research

R-loop ResolutionGenomic MechanismMolecular BiologyTumor BiologyCell Regulation +14

Inexpensive and rapid fabrication of PDMS microfluidic devices for biological testing applications using low cost commercially available 3D printers

Megala Ramasamy, Brandon Ho, Chau‐Minh Phan, +2

Journal of Micromechanics and Microengineering

Available 3DEngineeringBiomimetic MaterialsAnalytical MicrosystemsBiofabrication +16