Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy

Yoshiyuki Hiki, Hiroko Odani, Mami Takahashi, +6

Kidney International

Glomerular DiseaseGlomerulonephritisBiochemistryMedicineIga Glomerulonephritis +9

Enzymatically deglycosylated human IgA1 molecules accumulate and induce inflammatory cell reaction in rat glomeruli

Takashi Sano, Yoshiyuki Hiki, Tohru Kokubo, +3

Nephrology Dialysis Transplantation

Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins.

Tohru Kokubo, Yosio Hiki, Hitoo Iwase, +4

Journal of the American Society of Nephrology

Cell AdhesionImmunologyGlycobiologyIga1 Hinge RegionEcm Proteins +21

Analyses of IgA1 hinge glycopeptides in IgA nephropathy by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Yosio Hiki, Atsushi Tanaka, Tohru Kokubo, +4

Journal of the American Society of Nephrology

EngineeringGlycobiologyBiological Mass SpectrometryPolysaccharideCarbohydrate-protein Interaction +18

Underglycosylation of IgA1 Hinge Plays a Certain Role for Its Glomerular Deposition in IgA Nephropathy

Yoshiyuki Hiki, Tohru Kokubo, Hitoo Iwase, +6

Journal of the American Society of Nephrology

IgA1 molecules produced by tonsillar lymphocytes are under-O-glycosylated in IgA nephropathy

Akeyo Horie, Yoshiyuki Hiki, Hiroko Odani, +7

American Journal of Kidney Diseases

InflammationAutoimmune DiseaseIga GlomerulonephritisImmunologyIga1 Molecules +9

Direct Evidence for Decreased Sialylation and Galactosylation of Human Serum IgA1 Fc O-Glycosylated Hinge Peptides in IgA Nephropathy by Mass Spectrometry

Hiroko Odani, Y Hiki, Mami Takahashi, +5

Biochemical and Biophysical Research Communications

GlomerulonephritisBiochemistryMedicineNatural SciencesIga Glomerulonephritis +9

Association of asialo-galactosyl beta 1-3N-acetylgalactosamine on the hinge with a conformational instability of Jacalin-reactive immunoglobulin A1 in immunoglobulin A nephropathy.

Yosio Hiki, Hitoo Iwase, Tohru Kokubo, +5

Journal of the American Society of Nephrology

Immunoglobulin A NephropathyRenal PathologyGlycobiologyImmunologyMolecular Biology +20

Evidence for involvement of IgA1 hinge glycopeptide in the IgA1-IgA1 interaction in IgA nephropathy.

Tohru Kokubo, Yosio Hiki, Hitoo Iwase, +5

Journal of the American Society of Nephrology

ImmunologyGlycobiologyPathologyIga1 Hinge RegionGlomerulonephritis +18

O-linked oligosaccharide on IgA1 hinge region in IgA nephropathy. Fundamental study for precise structure and possible role.

Yosio Hiki, Akira Horii, Hitoo Iwase, +4

PubMed

O-linked OligosaccharideBiochemistryIga GlomerulonephritisGlycobiologyIga1 Hinge Region +5