Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy

Chirag Krishna, Renzo G. DiNatale, Fengshen Kuo, +30

Cancer Cell

Therapy EfficacyCancer ImmunosurveillanceT-regulatory CellImmunologyTumor Immunity +9

Transcriptomic Profiling of the Tumor Microenvironment Reveals Distinct Subgroups of Clear Cell Renal Cell Cancer: Data from a Randomized Phase III Trial

A. Ari Hakimi, Martin H. Voss, Fengshen Kuo, +15

Cancer Discovery

Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells

Shun Li, Ming Liu, H. Mytrang, +11

Nature

Tumor ImmunologyCancer ImmunosurveillanceTh CellsImmunologyTumor Immunity +6

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

Rumela Chakrabarti, Toni Celià-Terrassa, Sushil Kumar, +14

Science

Mammary Stem CellsCell SpecializationMammary Gland DevelopmentSignaling PathwayCell Regulation +15

TGF-β suppresses type 2 immunity to cancer

Ming Liu, Fengshen Kuo, Kristelle J. Capistrano, +14

Nature

Cancer ImmunosurveillanceImmunologyTumor ImmunityT Cell ImmunityImmunotherapy +2

Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer

Briana G. Nixon, Fengshen Kuo, Liangliang Ji, +19

Immunity

Tumor-associated MacrophagesCancer ImmunosurveillanceMedicineImmunologyTumor Immunity +5

Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages

Mei Song, Oladapo Yeku, Sarwish Rafiq, +12

Nature Communications

Reprogramming tumour-associated macrophages to outcompete cancer cells

Xian Zhang, Shun Li, Isha Malik, +14

Nature

Outcompete Cancer CellsMedicineCancer BiologyCell BiologyCancer Research +2

Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread

Briana G. Nixon, Martha Stefanidou, Pedro M. M. Mesquita, +6

Journal of Virology

Viral PathogenesisImmunologyAntiviral DrugGriffithsin Protects MiceTranslational Medicine +15

Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies

Emily R. Kansler, Saïda Dadi, Chirag Krishna, +16

Nature Immunology

CytokineCancer ImmunosurveillanceImmunologyImmunologic MechanismAutoimmunity +7