Suzanne Geenen

Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats

Suzanne Geenen, James Yates, J. Gerry Kenna et al. · Integrative Biology · 2013 · 39 citations · Full text

Lipid Peroxidation, Pbpk Models, Glutathione Metabolism +18

HPLC–MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium

Suzanne Geenen, Cristina Guallar-Hoyas, Filippos Michopoulos et al. · Journal of Pharmaceutical and Biomedical Analysis · 2011 · 38 citations

Biochemistry, Medicine, Liver Physiology +10

Glutathione metabolism modeling: A mechanism for liver drug-robustness and a new biomarker strategy

Suzanne Geenen, Franco B. du Preez, Jacky L. Snoep et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 2013 · 36 citations

Systems Biology, Hepatology, Biochemistry +13

A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells

Justyna Józefczuk, Karl Kashofer, Ramesh Ummanni et al. · Frontiers in Physiology · 2012 · 26 citations · Full text

Immunology, Pathology, Experimental Pathology +26

A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism

Suzanne Geenen, Franco B. du Preez, Michael C. Reed et al. · European Journal of Pharmaceutical Sciences · 2011 · 22 citations

Glutathione Metabolism, Biochemistry, Metabolic Model +13