Ryan O’Kelly

An aged immune system drives senescence and ageing of solid organs

Matthew J. Yousefzadeh, Rafael R. Flores, Yi Zhu et al. · Nature · 2021 · 946 citations · Full text

Life Sciences, Cell Biology, Immunology +14

Senolytics reduce coronavirus-related mortality in old mice

Christina D. Camell, Matthew J. Yousefzadeh, Yi Zhu et al. · Science · 2021 · 322 citations · Full text

Education, Immunology, Infectious Diseases +17

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

Jing Zhao, Lei Zhang, Aiping Lu et al. · Aging · 2020 · 113 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Urinary Extracellular Vesicles Carrying Klotho Improve the Recovery of Renal Function in an Acute Tubular Injury Model

Cristina Grange, Elli Papadimitriou, Veronica Dimuccio et al. · Molecular Therapy · 2019 · 108 citations · Full text

Medicine, Molecular Medicine, Nephrology +16

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

Lei Zhang, Jing Zhao, Xiaodong Mu et al. · Aging Cell · 2021 · 78 citations · Full text

Education, Cell Biology, Molecular Medicine +17