Evolution from adherent to suspension: systems biology of HEK293 cell line development

Magdalena Malm, Rasool Saghaleyni, Magnus Lundqvist, +9

Scientific Reports

Hek293 Cell LinesCell CultureGene CharacterizationCytoskeletonCell Specialization +15

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

Ning Liang, Anastasius Damdimopoulos, Saioa Goñi, +20

Nature Communications

ImmunologyPathologyFatty Liver DiseaseInflammationMetabolic Syndrome +25

Synthesis, Characterization and Biological Evaluation of Ureidofibrate-Like Derivatives Endowed with Peroxisome Proliferator-Activated Receptor Activity

Letizia Porcelli, Federica Gilardi, Antonio Laghezza, +17

Journal of Medicinal Chemistry

PharmacotherapyChemical BiologyChemical DerivativeInsulin SignalingUreidofibrate-like Derivatives +18

Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases

Alessandra Ferrari, Erika Fiorino, Raffaella Longo, +9

International Journal of Obesity

ObesityMetabolic SyndromeNutritionHistone DeacetylasesBiochemistry +10

Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation

Antonio Laghezza, Luca Piemontese, Carmen Cerchia, +9

Journal of Medicinal Chemistry

LT175 Is a Novel PPARα/γ Ligand with Potent Insulin-sensitizing Effects and Reduced Adipogenic Properties

Federica Gilardi, Marco Giudici, Nico Mitro, +13

Journal of Biological Chemistry

Molecular determinants for nuclear receptors selectivity: Chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists

Antonio Carrieri, Marco Giudici, Mariagiovanna Parente, +10

European Journal of Medicinal Chemistry

Molecular PharmacologyChemometric AnalysisBiochemistryMedicinePharmacology +6

Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection

Laura Castiglioni, Alice Pignieri, Melania Fiaschè, +11

Journal of Hypertension

Evolution from adherent to suspension – systems biology of HEK293 cell line development

Magdalena Malm, Rasool Saghaleyni, Magnus Lundqvist, +10

Hek293 Cell LinesMolecular BiologyCell CultureGene CharacterizationCell Specialization +15