Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice

Christian Freichel, Manuela Neumann, Theresa M. Ballard, +8

Neurobiology of Aging

Neurodegenerative DiseasesNeurobiology Of DiseaseSynaptic NeuroscienceAmygdala PathologyDegenerative Pathology +6

Effects of aripiprazole/OPC-14597 on motor activity, pharmacological models of psychosis, and brain activity in rats

Rebecca E. Nordquist, Céline Risterucci, Jean‐Luc Moreau, +6

Neuropharmacology

NeuropsychologyPsychoactive DrugPsychiatryNeurophysiologyMotor Activity +11

Effect of phenytoin on sodium and calcium currents in hippocampal CA1 neurons of phenytoin-resistant kindled rats

Monika Jeub, Heinz Beck, E. Siep, +6

Neuropharmacology

Synaptic PlasticityHippocampal Ca1 NeuronsHyperpolarization (Biology)NeurophysiologyMedicine +10

Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus

Christian Freichel, Heidrun Potschka, Ulrich Ebert, +2

Neuroscience

Synaptic PlasticityNeurophysiologyNeuroanatomyPhysiologyNeurotransmitter +13

Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics

Christina L. Zuch de Zafra, Vito G. Sasseville, Steven S. Matsumoto, +9

Regulatory Toxicology and Pharmacology

InflammationOcular DiseaseAutoimmune DiseaseOphthalmologyOcular Biologic Therapeutics +9

5-Hydroxyindole-2-carboxylic Acid Amides: Novel Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity

Pascale David Pierson, Alec Fettes, Christian Freichel, +17

Journal of Medicinal Chemistry

Comparative assessment of immune complex-mediated hypersensitivity reactions with biotherapeutics in the non-human primate: Critical parameters, safety and lessons for future studies

Sven Kronenberg, Elisabeth Husar, Christine M. Schubert, +5

Regulatory Toxicology and Pharmacology

Comparative AssessmentAllergyAutoimmune DiseaseImmunotoxicologyLaboratory Immunology +9

Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold

Hans Richter, Christian Freichel, Jörg Huwyler, +9

Bioorganic & Medicinal Chemistry Letters

Drug TargetBiochemistryFunctional SelectivityMedicineMechanism Of Action +4

Gene expression‐based in vivo and in vitro prediction of liver toxicity allows compound selection at an early stage of drug development

Adrian Roth, Franziska Boess, Christian Landes, +7

Journal of Biochemical and Molecular Toxicology

PathologyCompound SelectionPharmacotherapyToxicological MechanismHepatotoxicity +15

Amygdala-kindling does not induce a persistent loss of GABA neurons in the substantia nigra pars reticulata of rats

Christian Freichel, Ulrich Ebert, Heidrun Potschka, +1

Brain Research

Neurobiological MechanismNeurophysiologyNeuroanatomyPhysiologyNeurotransmitter +8