The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression

Philippe Dhordain, Sabine Quief, Danièle Lantoine, +4

Nucleic Acids Research

The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain.

Clotilde Deweindt, Olivier Albagli, Florent Bernardin, +5

PubMed

Transcriptional RegulationSystems BiologyBtb/poz RegionCell RegulationAutonomous Repressing Domain +11

TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation.

E. Dallery, Sylvie Galiègue‐Zouitina, M Collyn-d'Hooghe, +7

PubMed

Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma

Claude Preudhomme, Christophe Roumier, Marie‐Paule Hildebrand, +8

Oncogene

Lymphoid NeoplasiaMalignant Blood DisorderPathologyMultiple MyelomaRhoh/ttf Gene +5

The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homomerisation in vivo.

Philippe Dhordain, Olivier Albagli, Stéphane Ansieau, +7

PubMed

Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci

Olivier Albagli, Danièle Lantoine, Sabine Quief, +6

Oncogene

Cell RegulationApoptosisMolecular BiologyCell DeathTriggers Apoptosis +7

Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF

Philippe Dhordain, Olivier Albagli, Nicole Honoré, +6

Oncogene

ChromatinProtein FunctionMedicineNatural SciencesMolecular Biology +6

Increased expression of the LAZ3 (BCL6) proto-oncogene accompanies murine skeletal myogenesis

Olivier Albagli, Philippe Dhordain, Danièle Lantoine, +5

Differentiation

Cell LineageDevelopmental BiologyProto-oncogene AccompaniesSkeletal MyogenesisGenetics +7

Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5′-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation

Sébastien Lahousse, Anne-Lise Smorowski, Claude Denis, +3

Gene

Structural FeaturesTranscriptional RegulationHeme HomeostasisMedicineGenetics +7

DNA Replication Progresses on the Periphery of Nuclear Aggregates Formed by the BCL6 Transcription Factor

Olivier Albagli, Catherine Lindon, Danièle Lantoine, +4

Molecular and Cellular Biology