The biochemical basis of microRNA targeting efficacy

Sean E. McGeary, Kathy S. Lin, Charlie Y. Shi, +4

Science

BioinformaticsArgonaute-mirna ComplexesFunctional GenomicsEngineeringMedicine +13

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

Stephen W. Eichhorn, Huili Guo, Sean E. McGeary, +7

Molecular Cell

ChromatinDevelopmental BiologyGeneticsGene ExpressionDominant Effect +9

RNA Bind-n-Seq: Quantitative Assessment of the Sequence and Structural Binding Specificity of RNA Binding Proteins

Nicole Lambert, Alex Robertson, Mohini Jangi, +3

Molecular Cell

Functional GenomicsNatural SciencesRna Binding ProteinsGeneticsRna Structure Prediction +11

Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

Vincent C. Auyeung, Igor Ulitsky, Sean E. McGeary, +1

Cell

Functional GenomicsNatural SciencesGeneticsSecondary StructureComputational Biology +8

Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression

Rémy Denzler, Sean E. McGeary, Alexandra C. Title, +3

Molecular Cell

Environmental SignalingMicrorna LevelsEngineeringGeneticsTarget-site Complementarity +17

The Dynamics of Cytoplasmic mRNA Metabolism

Timothy J. Eisen, Stephen W. Eichhorn, Alexander O. Subtelny, +4

Molecular Cell

Systems BiologyProtein BiosynthesisGene ExpressionMedicineCell Biology +4

A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells

Li Li, Sarah Bowling, Sean E. McGeary, +9

Cell

BioinformaticsFunctional GenomicsSingle Cell SequencingJoint LineageGenetics +11

The biochemical basis of microRNA targeting efficacy

Sean E. McGeary, Kathy S. Lin, Charlie Y. Shi, +2

EngineeringMirna SequencesMolecular BiologyBiochemical BasisTranscriptional Regulation +15

Multicolor microRNA FISH effectively differentiates tumor types

Neil Renwick, Pavol Čekan, Paul A. Masry, +21

Journal of Clinical Investigation

Tumor BiologyMedicineMelanomaPathologyCancer Genomics +13

MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position

Sean E. McGeary, Namita Bisaria, Thy Pham, +2

eLife

Mirna TargetingEngineeringGeneticsMolecular BiologyTranscriptional Regulation +14