Takeshi Takizawa

Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor

Daisuke Honma, Osamu Kanno, Jun Watanabe et al. · Cancer Science · 2017 · 139 citations · Full text

Medicine, Molecular Biology, Oncology +17

An Accurate Pharmacophore Mapping Method by NMR Spectroscopy

Yumiko Mizukoshi, Aya Abe, Takeshi Takizawa et al. · Angewandte Chemie International Edition · 2011 · 31 citations

Pharmacy, Chemistry, Medicinal Chemistry +11

Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium

Yumiko Mizukoshi, Koh Takeuchi, Yuji Tokunaga et al. · Science Advances · 2020 · 28 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +16

Conformational Plasticity of Cyclic Ras‐Inhibitor Peptides Defines Cell Permeabilization Activity

Koh Takeuchi, Misaki Imai, Yuji Tokunaga et al. · Angewandte Chemie International Edition · 2021 · 16 citations

Life Sciences, Biochemistry, Molecular Biology +17

Improvement of Ligand Affinity and Thermodynamic Properties by NMR‐Based Evaluation of Local Dynamics and Surface Complementarity in the Receptor‐Bound State

Yumiko Mizukoshi, Koh Takeuchi, Misa Arutaki et al. · Angewandte Chemie International Edition · 2016 · 10 citations

Pharmacy, Biophysics, Chemistry +17