Glycosylation of site-specific glycans of α1-acid glycoprotein and alterations in acute and chronic inflammation

Koji Higai, Yutaka Aoki, Yutaro Azuma, +1

Biochimica et Biophysica Acta (BBA) - General Subjects

GlycoproteomicsProtein GlycosylationInflammationBiochemistryNatural Sciences +13

Altered glycosylation of α1-acid glycoprotein in patients with inflammation and diabetes mellitus

Koji Higai, Yutaro Azuma, Yutaka Aoki, +1

Clinica Chimica Acta

GlycoproteomicsProtein GlycosylationMetabolic SyndromeInflammationBiochemistry +11

Amadori-modified glycated albumin predominantly induces E-selectin expression on human umbilical vein endothelial cells through NADPH oxidase activation

Koji Higai, Ayano Shimamura, Kojiro Matsumoto

Clinica Chimica Acta

BiochemistryMedicineLipid PeroxidationExtracellular MatrixEndothelial Dysfunction +6

Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors

Wei Li, Songpei Li, Koji Higai, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesPhytopharmacology +9

Interleukin‐1β induces sialyl Lewis X on hepatocellular carcinoma HuH‐7 cells via enhanced expression of ST3Gal IV and FUT VI gene

Koji Higai, Noriko Miyazaki, Yutaro Azuma, +1

FEBS Letters

Il-1 Beta StimulationImmunologyImmune RegulationPathologyImmunoediting +21

Transcriptional regulation of human  -galactoside  2,6-sialyltransferase (hST6Gal I) gene during differentiation of the HL-60 cell line

Atsuo Taniguchi, Yūko Hasegawa, Koji Higai, +1

Glycobiology

Transcriptional RegulationHuman CellDevelopmental BiologyProtein ExpressionCell Regulation +9

Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors

Tatsunori Sasaki, Wei Li, Koji Higai, +1

Bioorganic & Medicinal Chemistry Letters

Drug TargetCanthinone AlkaloidsBiochemistryMedicineMechanism Of Action +4

NF.KAPPA.B-p65 Dependent Transcriptional Regulation of Glycosyltransferases in Human Colon Adenocarcinoma HT-29 by Stimulation with Tumor Necrosis Factor .ALPHA.

Koji Higai, Saki Ishihara, Kojiro Matsumoto

Biological and Pharmaceutical Bulletin

Binding of sialyl Lewis X antigen to lectin-like receptors on NK cells induces cytotoxicity and tyrosine phosphorylation of a 17-kDa protein

Koji Higai, Akihiro Ichikawa, Kojiro Matsumoto

Biochimica et Biophysica Acta (BBA) - General Subjects

17-Kda ProteinLectin-like ReceptorsMedicineImmunologyTumor Immunity +11

Differentiation elicits negative regulation of human β‐galactoside α2,6‐sialyltransferase at the mRNA level in the HL‐60 cell line

Akiyoshi Taniguchi, Koji Higai, Yūko Hasegawa, +2

FEBS Letters

Molecular RegulationGlycobiologyCellular PhysiologyHuman β‐Galactoside α2,6‐SialyltransferaseMrna Level +17