Neuroprotective effect of astaxanthin on H2O2-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo

Yapeng Lu, Siyuan Liu, Hua Sun, +3

Brain Research

Cerebral Vascular RegulationReperfusion InjuryMedicineH2o2-induced NeurotoxicityToxicology +11

Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion

Feng Zhanbo, Yapeng Lu, Xiaomei Wu, +5

Journal of Ethnopharmacology

Traumatic Brain InjuryBrain DamageChronic Cerebral HypoperfusionBrain InjuryNeuroscience +6

Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia–reperfusion injury in vivo and in vitro

Bin Peng, Peng Zhao, Yapeng Lu, +4

Brain Research

InflammationCerebral Vascular RegulationReperfusion InjuryCell DeathCerebral Ischemia–reperfusion Injury +12

Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells

Yapeng Lu, Bo Wang, Qian Shi, +3

Scientific Reports

Ligustilide prevents cognitive impairment and attenuates neurotoxicity in d-galactose induced aging mice brain

Jiejia Li, Qing Zhu, Yapeng Lu, +4

Brain Research

MitophagyAlzheimer's DiseaseAgingMedicineAutophagy +7

Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema

Yan Xue, Xueting Wang, Baolan Wan, +7

Cell Communication and Signaling

Hydroxypropyl-Sulfobutyl-β-Cyclodextrin Improves the Oral Bioavailability of Edaravone by Modulating Drug Efflux Pump of Enterocytes

Wen-Ting Rong, Yapeng Lu, Qing Tao, +4

Journal of Pharmaceutical Sciences

Pharmaceutical ScienceOral BioavailabilityPharmacological StudyMedicineDrug Efflux Pump +3

Inhibition of Aβ aggregates in Alzheimer’s disease by epigallocatechin and epicatechin-3-gallate from green tea

Tingting Chen, Yanfei Yang, Shajun Zhu, +4

Bioorganic Chemistry

Medicinal ChemistryNeurodegenerative DiseasesAlzheimer's DiseaseAβ AggregatesBiochemistry +9

ZT-25, a new vacuolar H+-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells

Yapeng Lu, Rui Zhang, Siyuan Liu, +3

European Journal of Pharmacology

Cell AutophagyMitophagySignal TransductionSignaling PathwayInduces Apoptosis +11

The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia

Lei Yang, Dan Wang, Xueting Wang, +2

Biochemical and Biophysical Research Communications

InflammationBiochemistryHeme HomeostasisRedox RegulatorPhysiology +10