Kari R. Fonseca

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

Jill L. Silverman, Daniel G. Smith, Stacey J. Sukoff Rizzo et al. · Science Translational Medicine · 2012 · 252 citations · Full text

Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 <i>H</i> -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

Patrick R. Verhoest, Douglas S. Chapin, Michael L. Corman et al. · Journal of Medicinal Chemistry · 2009 · 201 citations · Full text

Reduction of Brain Kynurenic Acid Improves Cognitive Function

Rouba Kozak, Brian Campbell, Christine A. Strick et al. · Journal of Neuroscience · 2014 · 172 citations · Full text

Synaptic Transmission, Neurotransmitter, Clinical Neuroscience +20

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia

Amy B. Dounay, Marie Anderson, Bruce M. Bechle et al. · ACS Medicinal Chemistry Letters · 2012 · 88 citations · Full text

Kat Ii, Medicinal Chemistry, Biochemistry +13

Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo

Robin J. Kleiman, Douglas S. Chapin, Curt Christoffersen et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 79 citations