David A. Jans

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Leon Caly, Julian Druce, Mike Catton et al. · Antiviral Research · 2020 · 2.3K citations · Full text

Life Sciences, Infectious Diseases, Pharmacotherapy +12

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Kylie M. Wagstaff, Haran Sivakumaran, Steven M. Heaton et al. · Biochemical Journal · 2012 · 684 citations · Full text

Life Sciences, Biology, Molecular Biology +14

The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T‐antigen.

H. P. Rihs, David A. Jans, Haojun Fan et al. · The EMBO Journal · 1991 · 355 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +5

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

Sundy N.Y. Yang, Sarah C. Atkinson, Chunxiao Wang et al. · Antiviral Research · 2020 · 329 citations

Life Sciences, Cell Biology, Molecular Biology +14

Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin

Moon Y. F. Tay, Johanna E. Fraser, Wing Ki Chan et al. · Antiviral Research · 2013 · 328 citations

Life Sciences, Biology, Infectious Diseases +15