David A. Jans

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Leon Caly, Julian Druce, Mike Catton et al. · Antiviral Research · 2020 · 2.2K citations · Full text

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Kylie M. Wagstaff, Haran Sivakumaran, Steven M. Heaton et al. · Biochemical Journal · 2012 · 668 citations · Full text

Specific Inhibitor, Hiv-1 Integrase, Viral Replication +19

The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen.

H. P. Rihs, David A. Jans, Haojun Fan et al. · The EMBO Journal · 1991 · 350 citations · Full text

Chromatin, Signal Transduction, Natural Sciences +11

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

Sundy N.Y. Yang, Sarah C. Atkinson, Chunxiao Wang et al. · Antiviral Research · 2020 · 325 citations

Molecular Virology, Natural Sciences, Pathogenesis +7

Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin

Moon Y. F. Tay, Johanna E. Fraser, Wing Ki Chan et al. · Antiviral Research · 2013 · 320 citations

Virus Structure, Dengue Virus, Molecular Virology +7