Perfluorooctanesulfonic Acid and Perfluorohexanesulfonic Acid Alter the Blood Lipidome and the Hepatic Proteome in a Murine Model of Diet-Induced Obesity

Marisa Pfohl, Lishann Ingram, Emily Marques, +6

Toxicological Sciences

Lipid PeroxidationLipid SpeciesFatty Liver DiseaseOxidative StressObesity +16

Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice

Emily Marques, Marisa Pfohl, Adam Auclair, +6

Toxicology and Applied Pharmacology

HepatologyBiochemistryPerfluorooctanesulfonic AcidHepatic ProteomeLiver Physiology +12

Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes

Emily Marques, Marisa Pfohl, Wei Wei, +9

Toxicology and Applied Pharmacology

Replacement Per-HepatologyBiochemistryGene Expression SignaturesOxidative Stress +11

An ‘Omics Approach to Unraveling the Paradoxical Effect of Diet on Perfluorooctanesulfonic Acid (PFOS) and Perfluorononanoic Acid (PFNA)-Induced Hepatic Steatosis

Marisa Pfohl, Emily Marques, Adam Auclair, +5

Toxicological Sciences

Per- and polyfluoroalkyl substances (PFAS) augment adipogenesis and shift the proteome in murine 3T3-L1 adipocytes

Seyed Mohamad Sadegh Modaresi, Wei Wei, Emily Marques, +2

Toxicology

Augment AdipogenesisMetabolic SyndromeSignal TransductionPolyfluoroalkyl SubstancesBiochemistry +11

Developmental Perfluorooctanesulfonic acid (PFOS) exposure as a potential risk factor for late-onset Alzheimer’s disease in CD-1 mice and SH-SY5Y cells

Veronia Basaly, Jaunetta Hill, Syed Waseem Bihaqi, +3

NeuroToxicology

Sh-sy5y CellsNeurodegenerative DiseasesAlzheimer's DiseaseDevelopmental Perfluorooctanesulfonic AcidMedicine +12

Perfluorooctanesulfonic Acid (PFOS) Thwarts the Beneficial Effects of Calorie Restriction and Metformin

Deanna M. Salter, Wei Wei, Pragati Nahar, +2

Toxicological Sciences

Hepatoprotective and anti-inflammatory effects of a standardized pomegranate ( <i>Punica granatum</i> ) fruit extract in high fat diet-induced obese C57BL/6 mice

Marisa Pfohl, Nicholas A. DaSilva, Emily Marques, +6

International Journal of Food Sciences and Nutrition

The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure

Emily Marques, Juliana Agudelo, Emily M. Kaye, +7

Toxicology

Animal PhysiologyMetabolic SyndromeNutritionDevelopmental BiologyBody Composition +11

Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD)

Matthew Hamilton, Melissa M. Heintz, Marisa Pfohl, +4

Food and Chemical Toxicology

BiochemistryCyp2b-null MiceMedicineLipid PeroxidationPhysiology +8