A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

Ayşegül Durak, Yusuf Olğar, Sinan Değirmenci, +3

Cardiovascular Diabetology

Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart

Erkan Tuncay, Ceylan Verda Bitirim, Ayşegül Durak, +3

Diabetes

Aging related functional and structural changes in the heart and aorta: MitoTEMPO improves aged-cardiovascular performance

Yusuf Olğar, Sinan Değirmenci, Ayşegül Durak, +5

Experimental Gerontology

Aged-cardiovascular PerformanceHypertensionHeart FailureKinesiologyAging +10

Zn2+-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes

Erkan Tuncay, Ceylan Verda Bitirim, Yusuf Olğar, +3

Mitochondrion

Cardiac MuscleCardiomyopathyHeart FailureMolecular PhysiologyMitochondrial Function +11

Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction

Esma N. Okatan, Ayşegül Durak, Belma Turan

Canadian Journal of Physiology and Pharmacology

Increased free Zn²⁺ correlates induction of sarco(endo)plasmic reticulum stress <i>via</i> altered expression levels of Zn²⁺‐transporters in heart failure

Yusuf Olğar, Ayşegül Durak, Erkan Tuncay, +7

Journal of Cellular and Molecular Medicine

Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts

Ayşegül Durak, Belma Turan

Journal of Physiology and Biochemistry

Heart FailureAgingMitochondrial FunctionCardiovascular DiseaseMitochondrial Dysfunction +8

Interplay Between Cytosolic Free Zn2+ and Mitochondrion Morphological Changes in Rat Ventricular Cardiomyocytes

Deniz Billur, Erkan Tuncay, Esma N. Okatan, +5

Biological Trace Element Research

Cardiac MuscleCardiomyopathyHeart FailureMolecular PhysiologyRat Ventricular Cardiomyocytes +9

Onset of decreased heart work is correlated with increased heart rate and shortened QT interval in high-carbohydrate fed overweight rats

Ayşegül Durak, Yusuf Olğar, Erkan Tuncay, +5

Canadian Journal of Physiology and Pharmacology

Metabolic DisorderCardiometabolic RiskCardiovascular FunctionObesityMetabolic Syndrome +16

The Relationship Between Metabolic Syndrome Development and Tissue Trace Elements Status and Inflammatory Markers

Sevginur Akdaş, Belma Turan, Ayşegül Durak, +1

Biological Trace Element Research

InflammationObesityMetabolic SyndromeBody CompositionMetabolic Disorder +10