Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer

Lawrence Fong, Andrew Hotson, John D. Powderly, +30

Cancer Discovery

Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome

Chao Yang, Jason Siebert, Robert Burns, +11

Nature Communications

STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models

Weiqing Jing, Donna McAllister, Emily P. Vonderhaar, +5

Journal for ImmunoTherapy of Cancer

Sting Agonist TreatmentT-regulatory CellImmunologyImmune RegulationImmunoediting +18

Deletion of Cbl-b inhibits CD8⁺ T-cell exhaustion and promotes CAR T-cell function

Jitendra Kumar, Ritesh Kumar, Amir Kumar Singh, +6

Journal for ImmunoTherapy of Cancer

Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3

Viktor Janzen, Heather E. Fleming, Tamara Riedt, +9

Cell stem cell

Signal TransductionExogenous Signals IsMedicineStem Cell MobilizationHematology +8

Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases

Matthew J. Riese, Liang‐Chuan S. Wang, Edmund K. Moon, +5

Cancer Research

ImmunologyImmune RegulationImmunoeditingImmunologic MechanismCar Activity +20

PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

Ekaterina Bobrovnikova-Marjon, Dariusz Pytel, Matthew J. Riese, +5

Molecular and Cellular Biology

Mediate Akt ActivationCell DeathEr StressCellular PhysiologyInsulin Signaling +19

Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma

David L. Bajor, Rosemarie Mick, Matthew J. Riese, +15

OncoImmunology

Epacadostat plus nivolumab in patients with advanced solid tumors: Preliminary phase I/II results of ECHO-204.

Raymond P. Perez, Matthew J. Riese, Karl D. Lewis, +8

Journal of Clinical Oncology

Oncologic ImagingE 300PharmacotherapyAdvanced Solid TumorsNeuro-oncology +14

The ζ Isoform of Diacylglycerol Kinase Plays a Predominant Role in Regulatory T Cell Development and TCR-Mediated Ras Signaling

Rohan P. Joshi, Amanda M. Schmidt, Jayajit Das, +7

Science Signaling

T-regulatory CellImmunologyImmune RegulationT CellsTcr-stimulated Ras Activation +15