Yixuan Lei

Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains

Bin Song, Yun Chen, Xin Liu et al. · Immunity · 2021 · 52 citations

Engineering, Rna Structure Prediction, Rna Biology +4

A loosened gating mechanism of RIG-I leads to autoimmune disorders

Yixuan Lei, Panyu Fei, Bin Song et al. · Nucleic Acids Research · 2022 · 24 citations · Full text

Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer

Weitao Fu, Hao Yang, Chenxian Hu et al. · ACS Central Science · 2023 · 18 citations · Full text

Androgen Receptor, Drug Target, Androgen Receptor Dimerization +17

Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening

Xueping Hu, Yang Liu, Xin Chai et al. · Acta Pharmacologica Sinica · 2021 · 16 citations · Full text

Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers

Weitao Fu, Minkui Zhang, Jianing Liao et al. · Journal of Medicinal Chemistry · 2021 · 16 citations · Full text