Piperazine and Piperidine Triazole Ureas as Ultrapotent and Highly Selective Inhibitors of Monoacylglycerol Lipase

Niina Aaltonen, Juha R. Savinainen, Casandra Riera Ribas, +14

Chemistry & Biology

Molecular PharmacologyHighly Selective InhibitorsBiochemistryPiperidine Triazole UreasMedicine +5

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

Ashik Jawahar Deen, Uma Thanigai Arasu, Sanna Pasonen‐Seppänen, +9

Cellular and Molecular Life Sciences

Udp-sugar SubstratesSignal TransductionCell RegulationMedicineMelanoma +10

Extracellular ATP activates hyaluronan synthase 2 (<i>HAS2</i>) in epidermal keratinocytes via P2Y2, Ca2+ signaling, and MAPK pathways

Leena Rauhala, Tiina Jokela, Riikka Kärnä, +6

Biochemical Journal

M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling

Kirsi Kainulainen, Piia Takabe, Sami Heikkinen, +11

Journal of Investigative Dermatology

Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling

Sanna Pasonen‐Seppänen, Piia Takabe, Michael Edward, +4

Histochemistry and Cell Biology

Hyaluronan SynthesisCutaneous BiologyMelanomaP38 SignalingDermatology +8

Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion

Piia Takabe, Geneviève Bart, Antti Ropponen, +4

Experimental Cell Research

MedicineMelanomaCancer Cell BiologyHyaluronan Synthase 3Cell-matrix Interaction +10

Interleukin-1β-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats

Tiina Jokela, Sanna Oikari, Piia Takabe, +4

Journal of Biological Chemistry

Cell AdhesionInterleukin-1β-induced ReductionImmunologyImmune RegulationSerine 325 +20

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

Ashik Jawahar Deen, Simone Adinolfi, Jouni Härkönen, +16

Redox Biology

Melanocyte Hyaluronan Coat Fragmentation Enhances the UVB-Induced TLR-4 Receptor Signaling and Expression of Proinflammatory Mediators IL6, IL8, CXCL1, and CXCL10 via NF-κB Activation

Piia Takabe, Riikka Kärnä, Leena Rauhala, +3

Journal of Investigative Dermatology

Metformin Decreases Hyaluronan Synthesis by Vascular Smooth Muscle Cells

Annele Sainio, Piia Takabe, Sanna Oikari, +5

Journal of Investigative Medicine