Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals.

Daniel Dusser, T. D. Djokic, D. B. Borson, +1

Journal of Clinical Investigation

AsthmaTobacco ControlAirway NepSmoke SolutionRespiratory Toxicology +13

Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase

David B. Jacoby, Jun Tamaoki, D. B. Borson, +1

Journal of Applied Physiology

Influenza InfectionLung InflammationRespiratory DiseasesFerret Tracheal SegmentsPathogenesis +12

Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea.

Kiyohisa Sekizawa, Jun Tamaoki, P. D. Graf, +3

Journal of Pharmacology and Experimental Therapeutics

Virus induces airway hyperresponsiveness to tachykinins: role of neutral endopeptidase

Daniel Dusser, David B. Jacoby, T. D. Djokic, +3

Journal of Applied Physiology

Animal PhysiologyMolecular PhysiologyAirway ResponsivenessPathogenesisImmunology +13

Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea

Kiyohisa Sekizawa, Jun Tamaoki, J A Nadel, +1

Journal of Applied Physiology

Smooth Muscle ContractionAnesthetic MechanismSubstance P-Experimental PharmacologyCellular Physiology +17

Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs.

Hirotsugu Kohrogi, P. D. Graf, Kiyohisa Sekizawa, +2

Journal of Clinical Investigation

AsthmaMolecular PharmacologyAwake Guinea PigsCapsaicin AerosolsCapsaicin-induced Cough +13

Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase.

Dean Sheppard, James E. Thompson, L. Scypinski, +3

Journal of Clinical Investigation

Molecular PharmacologyToluene Diisocyanate IncreasesLung InflammationMedicineRespiratory Toxicology +13

Neutral endopeptidase and neurogenic inflammation in rats with respiratory infections

D. B. Borson, James J. Brokaw, Kiyohisa Sekizawa, +2

Journal of Applied Physiology

AsthmaInflammatory Lung DiseaseLung InflammationImmunologySubstance P +18

Airway neutral endopeptidase-like enzyme modulates tachykinin-induced bronchoconstriction in vivo

Daniel Dusser, Eisuke Umeno, P. D. Graf, +3

Journal of Applied Physiology

AsthmaInflammationInflammatory Lung DiseaseLung InflammationMedicine +10

Enkephalinase Inhibitors Potentiate Substance P-Induced Secretion of³⁵SO₄-Macromolecules from Ferret Trachea

D. B. Borson, R. Corrales, Shabtai Varsano, +5

Experimental Lung Research